Sexual conflict maintains variation at an insecticide
resistance locus
Wayne G Rostant13, Caroline Kay2, Nina Wedell1 and David J
Hosken1*
* Corresponding author: David
J Hosken d.j.hosken@exeter.ac.uk
Author Affiliations
1 Centre for Ecology & Conservation, University of
Exeter, Cornwall Campus, Tremough, Penryn TR10 9FE, Cornwall, UK
2 Department of Biology & Bichemistry, University of
Bath, Bath BA2 7AY, UK
3 Present address: School of Biological Sciences, University
of East Anglia, Norwich NR4 7TJ, Norfolk, UK
For all author emails, please log on.
Biology 2015, 13:34
doi:10.1186/s12915-015-0143-3
The electronic version of this article is the complete one
and can be found online at:
Received: 9
January 2015
Accepted: 15 May
2015
Published: 29
June 2015
© 2015 Rostant et al.
This is an Open Access article distributed under the terms
of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is
properly credited. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made
available in this article, unless otherwise stated.
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Abstract Background
The maintenance of genetic variation through sexually
antagonistic selection is controversial, partly because specific
sexually-antagonistic alleles have not been identified. The Drosophila DDT
resistance allele (DDT-R) is an exception. This allele increases female
fitness, but simultaneously decreases male fitness, and it has been suggested
that this sexual antagonism could explain why polymorphism was maintained at
the locus prior to DDT use. We tested this possibility using a genetic model
and then used evolving fly populations to test model predictions.
Results
Theory predicted that sexual antagonism is able to maintain
genetic variation at this locus, hence explaining why DDT-R did not fix prior
to DDT use despite increasing female fitness, and experimentally evolving fly
populations verified theoretical predictions.
Conclusions
This demonstrates that sexually antagonistic selection can
maintain genetic variation and explains the DDT-R frequencies observed in
nature. tomado de envio de bcm
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