Structure and
function of mitochondrial membrane protein complexes
Werner Kühlbrandt
- Correspondence:
Werner Kühlbrandtwerner.kuehlbrandt@biophys.mpg.de
Department of Structural Biology, Max Planck Institute of
Biophysics, Max von Laue Str. 3, Frankfurt am Main, D-60438, Germany
BMC Biology 2015, 13:89 doi:10.1186/s12915-015-0201-x
The electronic version of this article is the complete one
and can be found online at:http://www.biomedcentral.com/1741-7007/13/89
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Published:
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29 October 2015
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© 2015 Kühlbrandt.
Open AccessThis article is distributed under the terms of
the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/),
which permits unrestricted use, distribution, and reproduction in any medium,
provided you give appropriate credit to the original author(s) and the source,
provide a link to the Creative Commons license, and indicate if changes were
made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made
available in this article, unless otherwise stated.
Biological energy conversion in mitochondria is carried out
by the membrane protein complexes of the respiratory chain and the
mitochondrial ATP synthase in the inner membrane cristae. Recent advances in
electron cryomicroscopy have made possible new insights into the structural and
functional arrangement of these complexes in the membrane, and how they change
with age. This review places these advances in the context of what is already
known, and discusses the fundamental questions that remain open but can now be
approached. VER MAS EN : :http://www.biomedcentral.com/1741-7007/13/89
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